The role of NF- B-1 and NF- B-2-mediated resistance to apoptosis in lymphomas

The role of NF- B-1 and NF- B-2-mediated resistance to apoptosis in lymphomas

The NFB pathways have been implicated in tumorigenesis in several lymphoid malignancies, including non-Hodgkin’s and Hodgkin’s lymphomas. However, the antiapoptotic functions and the mechanism responsible for signaling through each NFB pathway remain to be elucidated. In the current study, lymphoma cell lines with constitutively active NFB were found to be resistant to inducers of the extrinsic...

NF- B Regulates Fas-Mediated Apoptosis in HIV-Associated Nephropathy

Nephropathy Michael J. Ross,* Scott Martinka, Vivette D. D’Agati, and Leslie A. Bruggeman *Division of Nephrology, Mount Sinai Medical Center, New York, New York; Rammelkamp Center for Education and Research and Department of Medicine, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; and Department of Pathology, Columbia University College of Phys...

the role of russia in transmission of energy from central asia and caucuses to european union

پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...

p53 stabilization is decreased upon NF B activation: A role for NF B in acquisition of resistance to chemotherapy

Chemotherapeutic agents simultaneously induce transcription factors p53 and NF B. p53 induction can activate an apoptotic program, and resistance to chemotherapy correlates with the loss of a functional p53 pathway. By contrast, NF B prevents apoptosis in response to chemotherapeutic agents. We have analyzed the p53 response in IKK1/2 / MEFs, which lack detectable NF B activity. Compared to WT ...

NF- B and AP-1 Connection: Mechanism of NF- B-Dependent Regulation of AP-1 Activity